Recent research supports that symptoms such as fatigue, anxiety, and dizziness can appear as early warning signs of multiple sclerosis (MS) up to 15 years before formal diagnosis.
Fatigue, anxiety, dizziness—new research shows these may be early warning signs of MS appearing 15 years before diagnosis.

Early Warning Signs For MS Discovered—Appear 15 Years Before Main Symptoms - Newsweek
Source: newsweek.com
Key Evidence
Newsweek and Neuroscience News report increased physician visits for fatigue, pain, dizziness, and anxiety starting about 15 years before MS diagnosis.
MedicalXpress highlights similar findings about early mental health symptoms preceding neurological signs.
Medical News on August 2, 2025 notes psychiatric issues such as anxiety and depression as potential early indicators of MS.
What the Evidence Shows
Multiple studies and recent findings indicate that individuals who later receive an MS diagnosis often experience a prodromal phase characterized by increased healthcare visits for non-specific symptoms including fatigue, anxiety, dizziness, and other mental health conditions. This phase can begin approximately 15 years prior to the onset of classical neurological symptoms or formal diagnosis. The evidence suggests that these early symptoms are part of a longer disease development process rather than isolated or unrelated complaints.
This understanding is supported by data showing increased general practitioner and psychiatrist visits well before MS is clinically identified. While these symptoms are not exclusive to MS and can be caused by many other conditions, their presence in combination with increased healthcare utilization patterns may serve as early indicators warranting further neurological evaluation.