The claim that 'layoffs are caused by Democrats' is misleading because while the White House and Republican officials blame Democrats for the government shutdown that is leading to layoffs, this is a political framing rather than an objective cause; the layoffs result from a complex budget impasse involving both parties.
Layoffs are caused by democrats.

Vance uses false claims to pin shutdown blame on Democrats as White House warns of layoffs - US politics | The Guardian
Source: theguardian.com
Key Evidence
The White House explicitly blames Democrats for the shutdown causing layoffs.
timesofindia.indiatimes.comtimesofindia.indiatimes.com'Layoffs are imminent': White House blames Democrats for federal layoffs; says...
thehill.comthehill.comWhite House: Federal government layoffs likely in the thousands
The government shutdown is a result of a fiscal impasse involving both parties.
nytimes.comnytimes.comU.S. Begins Shutdown That Could Lead to Mass Layoffs and Service Cuts
nytimes.comnytimes.comTrump Uses Shutdown to Maximize Pain for Democrats and Move Forward With Layoffs
Independent sources and fact-checkers identify some Republican claims as false or misleading in blaming only Democrats.
theguardian.comtheguardian.comVance uses false claims to pin shutdown blame on Democrats as White House warns...
What the Evidence Shows
Multiple sources report that the White House and Republican leaders publicly attribute the imminent federal layoffs to Democrats, blaming them for not cooperating to end the government shutdown.timesofindia.indiatimes.comtimesofindia.indiatimes.com'Layoffs are imminent': White House blames Democrats for federal layoffs; says...
foxnews.comfoxnews.comTrump says government shutdown layoffs are 'up to' Dems as standoff continues This shutdown has triggered layoffs of federal employees, including at agencies like the U.S. Patent and Trademark Office.+4 more
However, independent reporting and fact-checking highlight that this blame is part of a political dispute rather than a straightforward causal relationship. The shutdown and resulting layoffs stem from a budget deadlock involving both Republicans and Democrats negotiating over funding priorities.nytimes.comnytimes.comU.S. Begins Shutdown That Could Lead to Mass Layoffs and Service Cuts
bbc.combbc.comUS shutdown: White House says layoffs to begin 'imminently' Some sources note that claims by Republican figures such as Vice President Vance contain false or exaggerated elements when pinning blame solely on Democrats.+2 more
Therefore, attributing layoffs solely to Democrats oversimplifies the situation and ignores the shared responsibility in the budget standoff.