While Trump claimed he could reduce drug prices by extremely large percentages (500% to 1500%), expert analysis and fact-checks indicate that such dramatic reductions are unrealistic and not supported by current policy mechanisms.
Trump: This is somebody nobody else can do. I can get the drug prices down… 1000% 600% 500% 1500%. Numbers that are not even thought to be achievable.

FactVerify
Source: factverify.com
Key Evidence
Fact-checks from PBS and BBC note that while price reductions of up to 30-80% might be possible in some cases, claims of reductions exceeding 100% are impossible and misleading.
pbs.orgpbs.orgFact-checking Trump's claim that prescription drug price drops could happen...
nytimes.comnytimes.comDrugmakers Notch a $5 Billion Win in Republicans’ Policy Bill
Legislative analyses indicate some policies may limit savings rather than maximize them.
Official White House sources confirm ambitious goals but do not substantiate the extreme percentage figures.
whitehouse.govwhitehouse.govFact Sheet: President Donald J. Trump Announces Actions to Put American Patients...
What the Evidence Shows
The claim breaks down into several components: first, that Trump uniquely can achieve drug price reductions that nobody else can; second, that these reductions would be extraordinarily large, with figures cited as 1000%, 600%, 500%, and 1500%; and third, that these numbers are unprecedented and previously thought unachievable. Official White House statements and Trump's remarks emphasize ambitious goals to lower drug prices, with some references to potential savings of up to 30-80%.whitehouse.govwhitehouse.govFact Sheet: President Donald J. Trump Announces Actions to Put American Patients...
However, independent experts and fact-checkers caution that the procedural and legal complexities involved make immediate or extreme price drops unlikely.pbs.orgpbs.orgFact-checking Trump's claim that prescription drug price drops could happen...
nytimes.comnytimes.comDrugmakers Notch a $5 Billion Win in Republicans’ Policy Bill The percentages Trump cited exceed logical bounds since a price cannot be reduced by more than 100%, claims of reductions over 100% are mathematically impossible and thus misleading.
Furthermore, some analyses highlight that certain legislative changes may actually limit the scope of price negotiations, potentially reducing expected savings. The rhetoric of being the only person capable of achieving these results is subjective and unverifiable but serves as political hyperbole rather than an evidence-based assertion. Overall, while efforts to lower drug prices are ongoing and may yield meaningful savings, the specific extreme percentage reductions claimed are not supported by credible evidence or expert consensus.