The claim that babies get 80 different vaccines is false; babies typically receive multiple doses of a smaller number of vaccines protecting against various diseases, but the total number of distinct vaccines given is far fewer than 80.
Babies get 80 different vaccines.

Why Do Babies Get More Vaccines Than They Used To?
Source: whattoexpect.com
Key Evidence
Children typically receive about 15-16 shots by age 2 protecting against roughly a dozen diseases.
whattoexpect.comwhattoexpect.comWhy Do Babies Get More Vaccines Than They Used To?
The CDC and AAFP immunization schedules list fewer than 20 distinct vaccines administered through childhood, many as combination shots.
aafp.orgaafp.orgBirth Through Age 18 Immunization Schedule
healthpartners.comhealthpartners.comChildren’s vaccine schedule: The full CDC guidelines
The total number of doses over many years may be higher but does not equate to unique vaccines.
vaxopedia.orgvaxopedia.orgDo Kids Really Get 72 Doses of Vaccines?
forbes.comforbes.comHow Did Babies Survive In The 1980s With Half The Doses Of Only 7 Vaccines?
What the Evidence Shows
The claim that babies receive 80 different vaccines conflates the number of vaccine doses or antigens with the number of distinct vaccines. According to multiple reliable sources, babies today may receive around 15 to 16 vaccine shots by age 2, which protect against roughly 14 to 16 diseases. Some sources mention that children might receive up to about 70 doses in total over many years, but these doses are not all unique vaccines; many are multiple doses of the same vaccine or combination vaccines that protect against several diseases at once.
For example, the American Academy of Family Physicians and CDC immunization schedules show a series of vaccines given at specific ages, including combination vaccines like DTaP (diphtheria, tetanus, pertussis), IPV (polio), Hib (Haemophilus influenzae type b), hepatitis B, pneumococcal conjugate, and others. These schedules do not approach anywhere near 80 distinct vaccines for babies.
Sources also clarify that while the number of vaccine doses has increased compared to past decades due to protection against more diseases, the antigen load in modern vaccines is lower than before. The confusion often arises from counting each dose or each antigen separately rather than counting distinct vaccines.
Therefore, the statement that babies get "80 different vaccines" is misleading and inaccurate based on current immunization schedules and expert explanations.