While some Catholic bishops have expressed opposition to the 'big, beautiful bill,' there is no clear evidence that the Catholic Church as a whole has officially condemned it or that 20 bishops joined an interfaith letter declaring its passage a profound moral failure.
The Catholic Church has condemned the so-called "big, beautiful bill," with 20 bishops joining an Interfaith Letter declaring that its passage would represent a profound moral failure for American society as a whole.

FactVerify
Source: factverify.com
What the Evidence Shows
The claim states that the Catholic Church has condemned the 'big, beautiful bill' and that 20 bishops joined an interfaith letter calling its passage a profound moral failure for American society. The search results do not provide direct evidence of an official condemnation by the Catholic Church as an institution.
However, one source from America Magazine indicates that some U.S. Bishops, including Archbishop John C. Wester of Santa Fe, have spoken against the bill and urged Catholics to oppose it, framing it as a betrayal of the poor. This suggests that there is opposition among certain bishops but does not confirm a unified or official stance by the entire Catholic Church.
Additionally, there is no mention in the sources of an interfaith letter signed by 20 bishops specifically condemning the bill or labeling its passage a profound moral failure. The other sources are unrelated to the claim and focus on Catholic churches or general information about Catholicism.
Therefore, while opposition exists among some bishops, the claim overstates the extent and official nature of the Catholic Church's condemnation and the involvement of 20 bishops in an interfaith letter.