Nancy Kassebaum became the first woman to chair a major standing Senate committee, but she was not the first woman to lead a major Senate panel of any kind.
Nancy Kassebaum was the first woman to chair a major U.S. Senate panel.

Nancy Kassebaum Baker, former U.S. senator from Kansas, dies at 94 - Los Angeles Times
Source: latimes.com
Key Evidence
Newsweek reports that Kassebaum became the first woman to chair a major standing Senate committee in 1995.
The Topeka Capital-Journal reports that she was the second woman to chair a Senate standing committee, creating a direct qualification to the broader claim.
Multiple reports identify her as the only woman serving as a Senate committee chair when she retired, but that is not the same as being the first woman ever to chair a major Senate panel.
What the Evidence Shows
Nancy Kassebaum became chair of the Senate Labor and Human Resources Committee in 1995 after Republicans won control of the chamber. Newsweek describes her as the first woman to chair a major standing Senate committee, a narrower distinction than the claim states. The broader wording is contradicted by reporting from The Topeka Capital-Journal, which calls Kassebaum the second woman to chair a Senate standing committee. Other reports, including NBC News, The Hindu, The Hill, CNN and Newsday, say she was the only woman serving as a Senate committee chair when she announced her retirement, but they do not establish that she was the first woman ever to chair a major Senate panel.nbcnews.comnbcnews.comNancy Kassebaum Baker, former U.S. senator from Kansas, dies at 94
thehill.comthehill.comNancy Kassebaum Baker, former US senator from Kansas, dies at 94+5 more
The distinction matters. Kassebaum’s documented achievement was becoming the first woman to chair a major standing committee, not necessarily the first woman to chair any major Senate panel. Britannica confirms her Senate service and Kansas distinction but does not support the broader superlative.britannica.combritannica.comNancy Kassebaum | Kansas, Facts, & Biography Thus, the statement uses a real milestone but broadens it beyond the qualification supported by the strongest reporting. It would be accurate if revised to say that Kassebaum was the first woman to chair a major standing U.S. Senate committee.